ABSTRACT
Hydroalcoholic extract of Pycnocycla spinosa has a relaxant effect on ileum and inhibits castor oil induced diarrhoea in mice. However, effects of P. spinosa seed extracts on ileum and uterus hasn't been investigated. The aim of this study was to investigate effect of P. spinosa seed and extracts of the aerial part on rat ileum and uterus smooth muscle contraction. A 70% ethanol extract of seed and aerial parts of P. spinosa was prepared by a percolation method. Uterine horns or ileum were dissected from non-pregnant female Wistar rats [200-230g] and cut into longitudinal strips and mounted for isotonic recording under Ig tension in Tyrode's solution. Effects of the extracts were examined on tonic contractions induced by KC1 [80mM] on both tissues and on phasic spasm induced by oxytocin [0.002iu/ml] on the uterus. The aerial part extract inhibited rat ileum contractions induced by 80mM KC1 [IC[50] = 42 +/- 3.4 micro g/ml] in a concentration dependent manner and it also inhibited rat uterus contraction induced by 80 mM KC1. However, its inhibitory effects were observed with higher concentration of the extract [IC5o = 420+90 micro g/ml] and at concentration of 1.28mg/ml of the extract in the bath the response was 19+7%. The aerial part extract [40-640 micro g/ml] also reduced the evoked phasic response of uterus by oxytocin [IC[50] = 71 +/- 17.3 micro g/ml]. The seed extract reduced the uterus response to oxytocin in a concentration-dependent manner, and inhibited tissue response completely at 160 micro g/ml [IC[50] = 27 +/- 4 micro g/ml]. From this study it was concluded that the seed extract of P. spinosa have similar inhibitory properties on rat isolated uterus and ileum contractions, while the extract of the aerial part of P. spinosa is more selective inhibitor of ileum contraction, and at higher concentrations it also inhibits uterus spasm
Subject(s)
Female , Animals, Laboratory , Plants, Medicinal , Seeds , /drug effects , Muscle, Smooth/drug effects , Myometrium/drug effects , Rats, Wistar , Uterine Contraction/drug effects , Spasm/etiology , Spasm/prevention & control , Uterus , Plant Extracts , Parasympatholytics , Plant Components, AerialABSTRACT
Devido ao esforço excessivo da coluna lombar, é alta a incidência de lombalgia entre lixeiros. Este estudo visou avaliar a eficácia da técnica de energia muscular com relaxamento pós-isométrico (TEM/RPI) para reduzir a dor de lombalgias agudas mecânicas em coletores de lixo e verificar a repercussão da técnica sobre a amplitude de movimento. Do quadro de trabalhadores de uma empresa de coleta de lixo, foram selecionados todos os portadores de lombalgia aguda.
Due to excessive effort at the lower back, there is a high incidence of low-back pain among garbage collectors. This study assessed the efficacy of a technique of muscle energy with post-contraction relaxation to reduce pain among garbage collectors with acute mechanical low-back pain...
Subject(s)
Male , Adolescent , Adult , Humans , Occupational Diseases/rehabilitation , Low Back Pain/therapy , Spasm/prevention & controlABSTRACT
Este trabajo se diseñó para evaluar la efectividad de diversos vasodilatadores aplicados tópicamente para prevenir la hiperreactividad de las arterias radiales (AR) implantadas como bypass aortocoronario. De cada uno de los remanentes de AR provenientes de 20 pacientes operados se obtuvieron 4 anillos que se incubaron por 30 minutos en condiciones control (n = 20) o en presencia de 30 µM de diltiazem (DILT, n = 6), mibefradil (MIBE, n = 4) o mezcla de verapamil + nitroglicerina (VP-NTG, n = 6). La subsiguiente exposición a CIK 80 mM (en ausencia de vasodilatadores) provocó una contracción sostenida en los anillos control, que fue atenuada en un 35 ñ 9 por ciento por DILT, 48 ñ 13 por ciento por VP-NTG y 69 ñ 20 por ciento por MIBE (p < 0.05). La preincubación con vasodilatadores provocó también la disminución de frecuencia e intensidad de contracciones rítmicas espontáneas de la AR. En anillos almacenados en frío por 24 hs y luego reestimulados con CIK 80 mM el efecto depresor fue aun evidente: DILT 53 ñ 6 por ciento, VP-NTG 46 ñ 14 por ciento y MIBE 61 ñ 9 por ciento (p < 0.05). El efecto del MIBE fue más intenso y persistente que el de DILT o VP-NTG, aún a concentraciones que provocan un igual efecto depresor inicial. Se concluye que la exposición a vasodilatadores durante un período equivalente a la duración de la preparación de la AR a implantar produce una atenuación de la reactividad arterial que proporcionaría una protección adicional contra el espasmo durante el postoperatorio inmediato.
Subject(s)
Humans , Middle Aged , Male , In Vitro Techniques , Radial Artery/drug effects , Vasodilator Agents/pharmacology , Coronary Artery Bypass/methods , Diltiazem/pharmacology , Mibefradil/pharmacology , Nitroglycerin/pharmacology , Radial Artery/surgery , Spasm/prevention & control , Verapamil/pharmacologyABSTRACT
Os autores apresentam os resultados do uso do antagonista de cálcio "Nimodipina" na profilaxia do vasoespasmo cerebral pós-hemorragia meníngea espontânea por rotura de aneurisma. O trabalho é baseado no estudo duplo-cego de 30 pacientes dos quais 15 receberam minodipina e 15 placebo. É ressaltada a gravidade desta complicaçäo nos sangramentos subaracnóideos. Os resultados säo semelhantes aos da literatura a respeito, aparentemente indicando um efeito benéfico da droga nestes pacientes